A genome-wide survey and functional brain imaging study identify CTNNBL1 as a 
memory-related gene

Papassotiropoulos, A; Stefanova, E; Vogler, C; Gschwind, L; Ackermann, S; Spalek, K; Rasch, B; Heck, A; Aerni, A; Hanser, E; Demougin, P; Huynh, KD; Luechinger, R; Klarhöfer, M; Novakovic, I; Kostic, V; Boesiger, P; Scheffler, Klaus; de Quervain, DJ-F

doi:10.1038/mp.2011.148

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene

MPS-Authors

/persons/resource/persons84187

Scheffler, Klaus
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

http://www.nature.com/mp/journal/v18/n2/pdf/mp2011148a.pdf
(Publisher version)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Papassotiropoulos, A., Stefanova, E., Vogler, C., Gschwind, L., Ackermann, S., Spalek, K., et al. (2013). A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene. Molecular Psychiatry, 18(2), 255-263. doi:10.1038/mp.2011.148.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-B4EA-9

Abstract

Unbiased genome-wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense genome-wide screen to identify episodic memory-related gene variants. A genomic locus encoding the brain-expressed beta-catenin-like protein 1 (CTNNBL1) was significantly (P=7 × 10−8) associated with verbal memory performance in a cognitively healthy cohort from Switzerland (n=1073) and was replicated in a second cohort from Serbia (n=524; P=0.003). Gene expression studies showed CTNNBL1 genotype-dependent differences in beta-catenin-like protein 1 mRNA levels in the human cortex. Functional magnetic resonance imaging in 322 subjects detected CTNNBL1 genotype-dependent differences in memory-related brain activations. Converging evidence from independent experiments and different methodological approaches suggests a role for CTNNBL1 in human memory.