A smart 19F and 1H MRI probe with self-immolative linker as a versatile tool 
for detection of enzymes

Keliris, A; Mamedov, I; Hagberg, GE; Logothetis, NK; Scheffler, K; Engelmann, J

doi:10.1002/cmmi.1470

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A smart 19F and 1H MRI probe with self-immolative linker as a versatile tool for detection of enzymes

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Keliris, A
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Mamedov, I
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Hagberg, GE
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis, NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84187

Scheffler, K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Engelmann, J
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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http://onlinelibrary.wiley.com/doi/10.1002/cmmi.1470/pdf
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Citation

Keliris, A., Mamedov, I., Hagberg, G., Logothetis, N., Scheffler, K., & Engelmann, J. (2012). A smart 19F and 1H MRI probe with self-immolative linker as a versatile tool for detection of enzymes. Contrast Media and Molecular Imaging, 7(5), 478-483. doi:10.1002/cmmi.1470.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-B612-0

Abstract

Here we report on a dual-modal 19F and 1H MRI paramagnetic probe with a self-immolative linker, Gd–DOMF–Gal. The enzymatic conversion of this probe by β-galactosidase resulted in a simultaneous turning on of the fluorine signal and changed ability of the Gd3+ complex to modulate the 1H MR signal intensity of the surrounding water molecules. A versatile imaging platform for monitoring a variety of enzymes by 19F and 1H MRI using this molecular design is proposed.