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Detailed functional and structural characterization of a macular lesion in a rhesus macaque

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Keliris,  GA
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Shao,  Y
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Smirnakis,  SM
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Fischer, M., Zobor, D., Keliris, G., Shao, Y., Seeliger, M., Haverkamp, S., et al. (2012). Detailed functional and structural characterization of a macular lesion in a rhesus macaque. Documenta Ophthalmologica, 125(3), 179-194. doi:10.1007/s10633-012-9340-3.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-B66C-6
Abstract
Animal models are powerful tools to broaden our understanding in disease mechanisms and to develop future treatment strategies. Here we present detailed structural and functional findings of a rhesus macaque suffering from a naturally occurring bilateral macular dystrophy (BMD), partial optic atrophy and corresponding reduction of central V1 signals in visual fMRI experiments when compared to data in a healthy macaque (CTRL) of similar age. Fluorescence and indocyanine green angiography showed reduced macular vascularization with significantly larger foveal avascular zones (FAZ) in the affected animal (FAZBMD = 8.85 mm2 vs. FAZCTRL = 0.32 mm2). Optical coherence tomography showed bilateral thinning of the macula within the FAZ (total retinal thickness, TRTBMD = 174 ± 9 μm) and partial optic nerve atrophy when compared to control (TRTCTRL = 303 ± 45 μm). Segmentation analysis revealed that inner retinal layers were primarily affected (inner retinal thickness, IRTBMD = 33 ± 9 μm vs. IRTCTRL = 143 ± 45 μm), while the outer retina essentially maintained its thickness (ORTBMD = 141 ± 7 μm vs. ORTCTRL = 160 ± 11 μm). Accordingly, a strong central reduction in the multifocal electroretinography and a specific attenuation of cone-derived signals in Ganzfeld electroretinography was found, whereas rod function remained normal. We provided detailed characterization of a primate macular disorder. This study aims to stimulate awareness and further investigation in primates with macular disorders eventually leading to the identification of a primate animal model and facilitating the preclinical development of therapeutic strategies.