Simultaneous single-quantum and triple-quantum-filtered MRI of 23Na (SISTINA)

Fiege, DP; Romanzetti, S; Mirkes, C; Brenner, D; Shah, NJ

doi:10.1002/mrm.24417

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Simultaneous single-quantum and triple-quantum-filtered MRI of 23Na (SISTINA)

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https://onlinelibrary.wiley.com/doi/epdf/10.1002/mrm.24417
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Fiege, D., Romanzetti, S., Mirkes, C., Brenner, D., & Shah, N. (2013). Simultaneous single-quantum and triple-quantum-filtered MRI of 23Na (SISTINA). Magnetic Resonance in Medicine, 69(6), 1691-1696. doi:10.1002/mrm.24417.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-B6BA-5

Abstract

The low MR sensitivity of the sodium nucleus and its low concentration in the human body constrain acquisition time. The use of both single-quantum and triple-quantum sodium imaging is, therefore, restricted. In this work, we present a novel MRI sequence that interleaves an ultra-short echo time radial projection readout into the three-pulse triple-quantum preparation. This allows for simultaneous acquisition of tissue sodium concentration weighted as well as triple-quantum filtered images. Performance of the sequence is shown on phantoms. The method is demonstrated on six healthy informed volunteers and is applied to three cases of brain tumors. A comparison with images from tumor specific O-(2-[18F]fluoroethyl)-L-tyrosine positron emission tomography and standard MR images is presented. The combined information of the triple-quantum-filtered images with single-quantum images may enable a better understanding of tissue viability. Future studies can benefit from the evaluation of both contrasts with shortened acquisition times.