Scyllo-Inositol detection in the human spinal cord

Hock, A; Fuchs, A; MacMillan, EL; Kreis, R; Kollias, SS; Boesiger, P; Henning, A

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Scyllo-Inositol detection in the human spinal cord

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Hock, A., Fuchs, A., MacMillan, E., Kreis, R., Kollias, S., Boesiger, P., et al. (2012). Scyllo-Inositol detection in the human spinal cord. Poster presented at 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-B7BA-E

Abstract

Scyllo-Inositol (sI) is one of the stereoisomers of inositol yielding to a singlet resonance at a chemical shift of 3.35 ppm in 1H MR spectroscopy (MRS). This work represents the first report of sI detection in the human spinal cord, which was enabled by non-water suppressed metabolite cycled 1H MRS at 3T. The results show an increased mI/Creatine and sI/Creatine ratio compared to the brain which might be an indicator of a different metabolism in the spinal cord.