Synthesis of Some Cyclic Methylene 1,3-Diaza Barbiturates Derivatives

Sweidan, K; Engelmann, J; Joshi, R; Mubarak, MS; El-Abadelah, MM

doi:10.2174/157017811797249353

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Synthesis of Some Cyclic Methylene 1,3-Diaza Barbiturates Derivatives

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Sweidan, K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Engelmann, J
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Joshi, R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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http://www.eurekaselect.com/88762/article
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Zitation

Sweidan, K., Engelmann, J., Joshi, R., Mubarak, M., & El-Abadelah, M. (2011). Synthesis of Some Cyclic Methylene 1,3-Diaza Barbiturates Derivatives. Letters in Organic Chemistry, 8(8), 603-605. doi:10.2174/157017811797249353.

Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0013-B98C-4

Zusammenfassung

The reaction of 1,3-dimethyl-5-bis(thioethyl)methylene barbituric acid (2) with various vic-diamines leads to the formation of the respective 1,3-diazamethylene barbiturate derivatives 3 (a-f) in high yields. Solid-state 13C-NMR, MS and IR spectral data were employed for the characterization of these compounds. Antimicrobial screening revealed that none of the newly synthesized compounds showed appreciable antibacterial activity.