English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Cation-Responsive MRI Contrast Agents Based on Gadolinium(III)

MPS-Authors
/persons/resource/persons83784

Angelovski,  G
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84074

Mamedov,  I
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Angelovski, G., & Mamedov, I. (2011). Cation-Responsive MRI Contrast Agents Based on Gadolinium(III). Current Inorganic Chemistry, 1(1), 76-90. doi:10.2174/1877944111101010076.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-BBA6-7
Abstract
Magnetic resonance imaging (MRI) offers the ability to visualize a number of biological processes at the molecular and cellular level. The quest for MRI methods that enable the monitoring of these processes with improved specificity and spatiotemporal resolution has induced a considerable amount of research into the chemistry of contrast agents. A novel class of agents has been developed that is able to report a change in its magnetic properties as a function of a specific parameter in the surrounding microenvironment. The vast majority consist of paramagnetic Gd3+ complexes that enhance the contrast in the MR image upon a change in the local concentration of a biologically relevant ion, such as H+, Ca2+, Zn2+, or Cu2+. This review summarizes their coordination chemistry and further aspects of these responsive paramagnetic complexes and discusses the most recent examples that are described in the literature.