Cross-validation of PRESS, MEGA-PRESS editing and 2D JPRESS for 
neurotransmitter and antioxidant detection at 3T using the ERETIC reference 
standard

Luttje, MP; Wyss, M; Zölch, N; Fuchs, A; Edden, RA; Heinzer, S; Bösiger, P; Henning, A

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Cross-validation of PRESS, MEGA-PRESS editing and 2D JPRESS for neurotransmitter and antioxidant detection at 3T using the ERETIC reference standard

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https://cds.ismrm.org/protected/11MProceedings/files/1_program.htm
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Luttje, M., Wyss, M., Zölch, N., Fuchs, A., Edden, R., Heinzer, S., et al. (2011). Cross-validation of PRESS, MEGA-PRESS editing and 2D JPRESS for neurotransmitter and antioxidant detection at 3T using the ERETIC reference standard. In 19th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2011).

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-BBF0-E

Abstract

SV PRESS, MEGA-PRESS and localized 2D JPRESS are compared to investigate their ability of quantifying GABA, Glu, Gln and GSH accurately. ERETIC has been applied as a reliable reference. Next to this, for all sequences the metabolite ratios with the internal water reference were calculated. JPRESS shows to be the best method for simultaneous quantification of the selected metabolites, while MEGA-PRESS GABA-editing proofs to be a faster and reliable method for studies that target mainly GABA. The metabolite/ERETIC ratio shows to be a more stable and hence reliable quantification method compared to the metabolite/water reference ratio for all tested sequences.