Signal characteristics of focal bone marrow lesions in patients with multiple 
myeloma using whole body T1w-TSE, T2w-STIR and diffusion-weighted imaging with 
background suppression

Sommer, G; Klarhöfer, M; Lenz, C; Scheffler, K; Bongartz, G; Winter, L

doi:10.1007/s00330-010-1950-0

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Signal characteristics of focal bone marrow lesions in patients with multiple myeloma using whole body T1w-TSE, T2w-STIR and diffusion-weighted imaging with background suppression

MPS-Authors

There are no MPG-Authors in the publication available

External Resource

https://link.springer.com/content/pdf/10.1007%2Fs00330-010-1950-0.pdf
(出版社版)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Sommer, G., Klarhöfer, M., Lenz, C., Scheffler, K., Bongartz, G., & Winter, L. (2011). Signal characteristics of focal bone marrow lesions in patients with multiple myeloma using whole body T1w-TSE, T2w-STIR and diffusion-weighted imaging with background suppression. European Radiology, 21(4), 857-862. doi:10.1007/s00330-010-1950-0.

引用: https://hdl.handle.net/11858/00-001M-0000-0013-BC32-3

要旨

Objective This study analyses the diagnostic potential of Diffusion-Weighted Imaging with Background Suppression (DWIBS) in the detection of focal bone marrow lesions from multiple myeloma. The signal and contrast properties of DWIBS are evaluated in correlation with the serum concentration of M-component (MC) and compared with established T1- and T2-weighted sequences. Methods Data from 103 consecutive studies in 81 patients are analysed retrospectively. Signal intensities and apparent Diffusion Coefficients (ADC) of 79 focal lesions in the lumbar spine or pelvis of 38 patients are determined and contrast-to-noise-ratio (CNR) is calculated. Data from patients with low (<20 g/L) and high (>20 g/dL) MC are evaluated separately. Results Signal intensities of focal myeloma lesions on T2w-STIR vary significantly depending on the MC, which leads to a loss in CNR in patients with high MC. No signal variation is observed for T1w-TSE and DWIBS. The CNR values provided by DWIBS in patients with high MC are slightly higher than those of T2w-STIR. ADC values in patients with low MC are significantly higher than in patients with high MC. Conclusion Whole-body DWIBS has the potential to improve the conspicuity of focal myeloma lesions and provides additional biological information by ADC quantification.