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Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-Based Propylphosphonates

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Mamedov,  I
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Angelovski,  G
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Mamedov, I., Táborský, P., Lubal, P., Laurent, S., Elst, L., Mayer, H., et al. (2009). Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-Based Propylphosphonates. European Journal of Inorganic Chemistry, 2009(22), 3298-3306. doi:10.1002/ejic.200900149.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-C36F-A
Abstract
Two DO3A-based ligands appended with the propylphosphonate side arm and their Ln3+ complexes were investigated. Proton relaxometric in vitro studies at 20 MHz and 60 MHz and 37 °C of the Gd3+ complex containing free acid exhibited relative changes of up to 56 in r1 relaxivity when the pH of the medium was changed from 4 to 7. This change is explained by the decrease in the number of coordinated water molecules from two to one. Temperature-dependent relaxivity and NMRD profiles of Gd3+ complexes showed a fast water exchange and a slightly increased rotational correlation time, which is characteristic of phosphonate-containing compounds. Thermodynamic and kinetic studies of the Gd3+ and Eu3+ complexes were performed by means of potentiometry and luminescence spectroscopy. The results indicate that the thermodynamic stability and kinetic inertness of these complexes are sufficient for their in vivo application.