Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Signals from the Edges: The Cortical Hem and Antihem in telencephalic development

There are no MPG-Authors in the publication available
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Subramanian, L., Remedios, R., Shetty, A., & Tole, S. (2009). Signals from the Edges: The Cortical Hem and Antihem in telencephalic development. Seminars in Cell and Developmental Biology, 20(6), 712-718. doi:10.1016/j.semcdb.2009.04.001.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-C373-D
The early cortical primordium develops from a sheet of neuroepithelium that is flanked by distinct signaling centers. Of these, the hem and the antihem are positioned as longitudinal stripes, running rostro-caudally along the medial and lateral faces, respectively, of each telencepahlic hemisphere. In this review we examine the similarities and differences in how these two signaling centers arise, their roles in patterning adjacent tissues, and the cells and structures they contribute to. Since both the hem and the antihem have been identified across many vertebrate phyla, they appear to be part of an evolutionary conserved set of mechanisms that play fundamental roles in forebrain development.