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17 O T1/T2* tissue-relaxation rates with anatomical contrast in the rat brain at 16.4 T

MPS-Authors
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Wiesner,  HM
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Balla,  DZ
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Pohmann,  R
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Uludag,  K
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Wiesner, H., Balla, D., Pohmann, R., Chen, W., Ugurbil, K., & Uludag, K. (2009). 17 O T1/T2* tissue-relaxation rates with anatomical contrast in the rat brain at 16.4 T. In 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2009).


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-C54F-F
Abstract
The direct NMR detection of 17O benefits particularly from higher field strengths and is a promising tool in the study of cerebral oxygen metabolism. The aim of this study was to acquire anatomical MRS images of H2O17 at natural abundance concentration in the rat head at 16.4 T. Intra-cortical contrast and differences in tissue-specific relaxation of brain and muscle tissue were found, enabling optimizations in contrast and sensitivity. Based on these results implications on the spatial specificity of oxygen consumption (CMRO2) measurements using 17O2-enriched gas are discussed.