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Highly Accurate Quantification of Proton MR Spectroscopy in Rat Brain in Vivo at 16.4 T

MPS-Authors
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Hong,  S-T
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Balla,  DZ
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Shajan,  G
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Pohmann,  R
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Hong, S.-T., Balla, D., Shajan, G., Ugurbil, K., & Pohmann, R. (2009). Highly Accurate Quantification of Proton MR Spectroscopy in Rat Brain in Vivo at 16.4 T. Poster presented at 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2009), Honolulu, HI, USA.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-C563-0
Abstract
In the present study, we used a 16.4 T scanner to evaluate the quantification of metabolites from the rat brain with an ultra-short TE STEAM sequence. All metabolite resonances, previously observed in vivo and published in the literature, were detected. Additionally, a newly discernible Histidine peaks at 3.11 ppm, 3.22 ppm and 3.97 ppm were detected and quantified for the first time in vivo, with CRLB of below 20 , indicating high quantification reliability. These preliminary results demonstrate the feasibility of detecting new metabolites in combination with the advantages of a high magnetic field strength.