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Liver tissue repair in a mouse model of toxicant-induced liver inury is associated with increased hepatic energy metabolism

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Gottschalk, S., Leibfritz, D., Zwingmann, C., & Bilodeau, M. (2009). Liver tissue repair in a mouse model of toxicant-induced liver inury is associated with increased hepatic energy metabolism. In 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2009).


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-C565-C
Abstract
Due to its ability regenerate, the liver is an ideal model for studying tissue repair mechanisms. Only little is known about the repair-associated changes in cellular metabolic pathways. Energy-intensive repair processes should be reflected in alterations in energy metabolism. An in vivo liver-injury model was used to generate an onset of liver tissue-repair. We assessed the extent of liver-injury and NMR-spectroscopy was used to characterize changes in energy metabolism and metabolites. Our results showed that induction of liver-regeneration was consistent with an up-regulation of the cells overall energy metabolism and a higher demand for TCA-cycle intermediates (eg. for amino-acids synthesis).