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Poster

Liver tissue repair in a mouse model of toxicant-induced liver inury is associated with increased hepatic energy metabolism

MPG-Autoren
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Gottschalk,  S
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zitation

Gottschalk, S., Leibfritz D, Zwingmann, C., & Bilodeau, M. (2009). Liver tissue repair in a mouse model of toxicant-induced liver inury is associated with increased hepatic energy metabolism. Poster presented at 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2009), Honolulu, HI, USA.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0013-C565-C
Zusammenfassung
Due to its ability regenerate, the liver is an ideal model for studying tissue repair mechanisms. Only little is known about the repair-associated changes in cellular metabolic pathways. Energy-intensive repair processes should be reflected in alterations in energy metabolism. An in vivo liver-injury model was used to generate an onset of liver tissue-repair. We assessed the extent of liver-injury and NMR-spectroscopy was used to characterize changes in energy metabolism and metabolites. Our results showed that induction of liver-regeneration was consistent with an up-regulation of the cells overall energy metabolism and a higher demand for TCA-cycle intermediates (eg. for amino-acids synthesis).