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Smart Magnetic Resonance Imaging Agents that Sense Extracellular Calcium Fluctuations

MPS-Authors
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Angelovski,  G
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Mamedov,  I
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Canals,  S
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Angelovski, G., Fousková, P., Mamedov, I., Canals, S., Tóth, É., & Logothetis, N. (2008). Smart Magnetic Resonance Imaging Agents that Sense Extracellular Calcium Fluctuations. ChemBioChem: A European Journal of Chemical Biology, 9(11), 1729-1734. doi:10.1002/cbic.200800165.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-C829-7
Abstract
Gd3+ chelates linked to a modified EGTA moiety were prepared in order to respond to extracellular Ca2+ fluctuations in the brain Gd3+ chelates linked to a modified EGTA moiety were prepared in order to respond to extracellular Ca2+ fluctuations in the brain. Upon interaction with Ca2+, they exhibit high and reversible relaxivity changes in buffered solution or in a model of the brain extracellular medium. These efficient Ca2+ magnetic resonance imaging sensors might open new perspectives in functional molecular imaging.