Smart Magnetic Resonance Imaging Agents that Sense Extracellular Calcium 
Fluctuations

Angelovski, G; Fousková, P; Mamedov, I; Canals, S; Tóth, É; Logothetis, NK

doi:10.1002/cbic.200800165

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Smart Magnetic Resonance Imaging Agents that Sense Extracellular Calcium Fluctuations

MPS-Authors

/persons/resource/persons83784

Angelovski, G
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84074

Mamedov, I
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84751

Canals, S
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84063

Logothetis, NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

https://onlinelibrary.wiley.com/doi/epdf/10.1002/cbic.200800165
(Publisher version)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Angelovski, G., Fousková, P., Mamedov, I., Canals, S., Tóth, É., & Logothetis, N. (2008). Smart Magnetic Resonance Imaging Agents that Sense Extracellular Calcium Fluctuations. ChemBioChem: A European Journal of Chemical Biology, 9(11), 1729-1734. doi:10.1002/cbic.200800165.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-C829-7

Abstract

Gd3+ chelates linked to a modified EGTA moiety were prepared in order to
respond to extracellular Ca2+ fluctuations in the brain

Gd3+ chelates linked to a
modified EGTA moiety were prepared in order to respond to extracellular Ca2+
fluctuations in the brain. Upon interaction with Ca2+, they exhibit
high and reversible relaxivity changes in buffered solution or in a model of
the brain extracellular medium. These efficient Ca2+ magnetic
resonance imaging sensors might open new perspectives in functional molecular
imaging.