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Covalent Pyrenebutyrate-Cell Penetrating Peptide Conjugates: Enhanced Direct Membrane Translocation of Coupled Molecular Imaging Agents

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Mishra,  R
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Su,  W
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Pfeuffer,  J
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Engelmann,  J
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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JCR-2008-Ritu.pdf
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Citation

Mishra, R., Su, W., Pfeuffer, J., Ugurbil, K., & Engelmann, J. (2009). Covalent Pyrenebutyrate-Cell Penetrating Peptide Conjugates: Enhanced Direct Membrane Translocation of Coupled Molecular Imaging Agents. In 35th Annual Meeting and Exposition of the Controlled Release Society 2008 (pp. 817-818). Red Hook, NY, USA: Curran.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-C8A1-A
Abstract
Intracellular targeting with cell penetrating
peptides (CPPs) is limited by endocytotic
mechanism of uptake. Here, we report that
the well known CPP, dTat, chemically
coupled with pyrenebutyrate (PB) can
efficiently deliver directly into the cytosol.
Results indicate that this combination could
successfully translocate magnetic resonance imaging (MRI) agents into cytosol.