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Conference Paper

Covalent Pyrenebutyrate-Cell Penetrating Peptide Conjugates: Enhanced Direct Membrane Translocation of Coupled Molecular Imaging Agents

MPS-Authors
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Mishra,  R
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Su,  W
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Pfeuffer,  J
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Engelmann,  J
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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JCR-2008-Ritu.pdf
(Any fulltext), 35KB

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Citation

Mishra, R., Su, W., Pfeuffer, J., Ugurbil, K., & Engelmann, J. (2009). Covalent Pyrenebutyrate-Cell Penetrating Peptide Conjugates: Enhanced Direct Membrane Translocation of Coupled Molecular Imaging Agents. In 35th Annual Meeting and Exposition of the Controlled Release Society 2008 (pp. 817-818). Red Hook, NY, USA: Curran.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-C8A1-A
Abstract
Intracellular targeting with cell penetrating peptides (CPPs) is limited by endocytotic mechanism of uptake. Here, we report that the well known CPP, dTat, chemically coupled with pyrenebutyrate (PB) can efficiently deliver directly into the cytosol. Results indicate that this combination could successfully translocate magnetic resonance imaging (MRI) agents into cytosol.