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Negative BOLD Signal Under 6 Hypercapnia Reflects Solely Oxygen Extraction from the Blood

MPS-Authors
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Zappe,  A-C
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Uludag,  K
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Zappe, A.-C., Uludag, K., & Logothetis, N. (2008). Negative BOLD Signal Under 6 Hypercapnia Reflects Solely Oxygen Extraction from the Blood. In 16th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008) (pp. 166).


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-C99D-E
Abstract
The BOLD signal is sensitive to cerebral blood flow (CBF), blood volume (CBV) and oxygen extraction. In the anesthetized monkey, we observe a vasodilatory ceiling effect during inhalation of 6 CO2 where CBF or CBV are not further increased by visual stimulation. In contrast, simultaneously measured local field potential responds to the stimulation as strong as during normocapnia. As a consequence, the stimulus-induced fMRI response during 6 hypercapnia has been found to be negative reflecting only the oxygen extraction from the blood. With this method, oxygen extraction can be imaged by means of fMRI without injection of an exogenous drug.