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Journal Article

Imaging in vivo: watching the brain in action

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Kerr,  JND
Former Research Group Network Imaging, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group Neural Population Imaging, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Kerr, J., & Denk, W. (2008). Imaging in vivo: watching the brain in action. Nature Reviews Neuroscience, 9(3), 195-205. doi:10.1038/nrn2338.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-CA17-1
Abstract
The appeal of in vivo cellular imaging to any neuroscientist is not hard to understand: it is almost impossible to isolate individual neurons while keeping them and their complex interactions with surrounding tissue intact. These interactions lead to the complex network dynamics that underlie neural computation which, in turn, forms the basis of cognition, perception and consciousness. In vivo imaging allows the study of both form and function in reasonably intact preparations, often with subcellular spatial resolution, a time resolution of milliseconds and a purview of months. Recently, the limits of what can be achieved in vivo have been pushed into terrain that was previously only accessible in vitro, due to advances in both physical-imaging technology and the design of molecular contrast agents.