Design, Synthesis and Characterization of Novel Exogenous Smart/Bioresponsive 
Contrast Agents for Magnetic Resonance and Optical Imaging

Mishra, A

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Design, Synthesis and Characterization of Novel Exogenous Smart/Bioresponsive Contrast Agents for Magnetic Resonance and Optical Imaging

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Mishra, A
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Mishra, A. (2008). Design, Synthesis and Characterization of Novel Exogenous Smart/Bioresponsive Contrast Agents for Magnetic Resonance and Optical Imaging.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-CA91-B

Abstract

Magnetic Resonance Imaging (MRI) is a valuable and versatile technique for visualizing internal structures first described in 19781. It is an extension of Nuclear Magnetic Resonance (NMR) spectroscopy used in chemistry. Molecular imaging using magnetic resonance techniques is a rapidly growing field in diagnostic medicine and basic neuroscience. The high spatial resolution and the undisputed capacity of differentiating soft tissues have highly contributed to the widespread use of this imaging modality. MRI offers the potential of realistic three dimensional imaging of biological structures, where the signal is based upon the resonance of water protons. With the advent of improved variety of technologies both in terms of hardware/software and the versatile techniques, it is possible to obtain detailed anatomical, physiological and metabolic/functional information with carefully designed experiments, which could address various intriguing questions concerning neural mechanisms of cognitive functions in the primate, which is the thrust area of our research.