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Thesis

Design, Synthesis and Characterization of Novel Exogenous Smart/Bioresponsive Contrast Agents for Magnetic Resonance and Optical Imaging

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Mishra,  A
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://publikationen.uni-tuebingen.de/xmlui/handle/10900/49135
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Citation

Mishra, A. (2008). Design, Synthesis and Characterization of Novel Exogenous Smart/Bioresponsive Contrast Agents for Magnetic Resonance and Optical Imaging. PhD Thesis, Eberhard-Karls-Universität, Tübingen, Germany.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-CA91-B
Abstract
Magnetic Resonance Imaging (MRI) is a valuable and versatile technique for
visualizing internal structures first described in 19781. It is an extension of Nuclear
Magnetic Resonance (NMR) spectroscopy used in chemistry. Molecular imaging
using magnetic resonance techniques is a rapidly growing field in diagnostic medicine
and basic neuroscience. The high spatial resolution and the undisputed capacity of
differentiating soft tissues have highly contributed to the widespread use of this
imaging modality. MRI offers the potential of realistic three dimensional imaging of
biological structures, where the signal is based upon the resonance of water protons.
With the advent of improved variety of technologies both in terms of
hardware/software and the versatile techniques, it is possible to obtain detailed
anatomical, physiological and metabolic/functional information with carefully
designed experiments, which could address various intriguing questions concerning
neural mechanisms of cognitive functions in the primate, which is the thrust area of
our research.