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Synthesis and Relaxation Properties of Three Novel Bis-macrocycles: Attempt towards Calcium Sensitive MRI Contrast Agents

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Mishra,  A
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Fousková P, Balogh E, Angelovski,  G
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Mishra, A., Fousková P, Balogh E, Angelovski, G., Logothetis, N., & Tóth, É. (2007). Synthesis and Relaxation Properties of Three Novel Bis-macrocycles: Attempt towards Calcium Sensitive MRI Contrast Agents. Poster presented at AMI/SMI Joint Molecular Imaging Conference 2007, Providence, RI, USA.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-CC21-A
Abstract
MR contrast agents whose efficiency depends on the concentration of signaling molecules may be used to directly visualize neuronal activation. The so-called ‘smart’ contrast agents for magnetic resonance imaging exhibit dynamic and reversible modulation of their relaxivity by specific physiological or biochemical triggers such as changes in pH, Ca2+ concentration or enzymatic activity. The extracellular concentration of Ca2+ plays an important role in the physiological and pathological processes of the nervous system; it led us to design chelating systems in which the relaxivity is influenced by the Ca2+ concentration. We synthesized three novel bifunctional bismacrocycles based on DO3A-EA coupled to EDTA/DTPA-bisanhydride via amide bonds.