Changes in specific metabolic pathways are essential steps in the early 
apoptotic process in the liver

Gottschalk, S; Chan , TS; Raymond, V-A; Bilodeau, M; Leibfritz, D; Zwingmann, C

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

ポスター

Changes in specific metabolic pathways are essential steps in the early apoptotic process in the liver

MPS-Authors

There are no MPG-Authors in the publication available

External Resource

https://cds.ismrm.org/ismrm-2006/files/program.pdf
(要旨)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

ISMRM-2006-Gottschalk.pdf
(全文テキスト（全般）), 43KB

付随資料 (公開)

There is no public supplementary material available

引用

Gottschalk, S., Chan, T., Raymond, V.-A., Bilodeau, M., Leibfritz, D., & Zwingmann, C. (2006). Changes in specific metabolic pathways are essential steps in the early apoptotic process in the liver. Poster presented at 14th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2006), Seattle, WA, USA.

引用: https://hdl.handle.net/11858/00-001M-0000-0013-D1FB-C

要旨

the immunosuppressant Cyclosporine A (CsA), we used multinuclear NMR spectroscopy and molecular studies to characterize metabolic pathways in mice liver during anti-Fas-induced apoptosis. An upregulation of specific metabolic pathways of glucose was the earliest indicator of the effect of Fas on the liver. CsA prevented apoptosis and energy failure at late stages, while the reversal of Fas-induced metabolic upregulation at early stages preceded the protective effect of EGF on programmed cell death. These phenomena provide useful hints for the understanding of early mechanisms controlling apoptotic cell death.