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Determination of tiopronin in human plasma by HPLC-MS with precolumn derivatization.

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Li, J., Bi, S., & Chen, H. (2006). Determination of tiopronin in human plasma by HPLC-MS with precolumn derivatization. Chinese Journal of New Drugs and Clinical Remedies, 25(6), 421-423.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-D305-6
Abstract
Tiopronin (2-mercaptopropionylglycine, TP) is a thiol compound, which has been used as a hepatoprotective and anti-cataract agent. It also modifies rheumatoid arthritis and has been applied in the treatment of cystinuria. In this study, a sensitive and reproducible HPLC-MS method has been developed for the analysis of tiopronin in human plasma. Pre-column derivatization with 2, 4-dinitrofluorobenzene (DNCB), the blood plasma was de-proteinized and purified by liquid-liquid extraction. This assay method was successively applied to a pharmacokinetics study.