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Multifunctional gadolinium-based ligand DO3A-EA as novel precursor for conjugation with bioorganic molecules to develop smart contrast agents for MR imaging

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Mishra,  A
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Pfeuffer,  J
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Mishra,  R
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84083

Mishra,  AK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Mishra, A., Pfeuffer, J., Mishra, R., Logothetis, N., & Mishra, A. (2005). Multifunctional gadolinium-based ligand DO3A-EA as novel precursor for conjugation with bioorganic molecules to develop smart contrast agents for MR imaging. Poster presented at 13th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2005), Miami Beach, FL, USA.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-D5A9-2
Abstract
Smart MR contrast agents are chelated paramagnetic molecules, whose relaxivity changes as a function of their chemical environment (e.g. changes in pH, calcium or neurotransmitter concentration). The multifunctional chelating agent DO3A-EA has been designed and synthesized as a valuable multifunctional precursor for smart MR contrast agents based on Gd-chelates. DO3A-EA was conjugated with diverse bioorganic molecules: 1) Gd-preloaded precursor Gd-DO3A-E-NCS with a highly reactive electrophile group for interaction with biological molecules or further synthesis. 2) Biotin-conjugated Gd-DO3A-E-Biotin for targeted imaging in an antibody-avidin system. 3) Fluorescence probe DO3A-E-FITC to track cell internalization and binding.