Enantioselective oxidation of racemic 1,2-propanediol to -(−)-lactic acid by 
Gluconobacter oxydans

W, Su; Z, Chang; K, Gao; D, Wei

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Enantioselective oxidation of racemic 1,2-propanediol to -(−)-lactic acid by Gluconobacter oxydans

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引用

W, S., Z, C., K, G., & D, W. (2004). Enantioselective oxidation of racemic 1,2-propanediol to -(−)-lactic acid by Gluconobacter oxydans. Tetrahedron: Asymmetry, Volume 15(Issue 8,), 1275-1277. Retrieved from Tetrahedron: Asymmetry.

引用: https://hdl.handle.net/11858/00-001M-0000-0013-D975-3

要旨

Gluconobacter oxydans DSM 2003 was firstly used in the production of (R)-2-hydroxy-propionic acid through microbial oxidation of racemic 1,2-propanediol. The biotransformation was processed with high enantiomeric excess (>99) and near theoretical yield (48 of racemic 1,2-propanediol) when the substrate concentration was lower than 20 g/L. When the substrate concentration was increased, maintaining the pH at 6.0 helped to improve the enantioselectivity.