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The Negative BOLD Response in Monkey V1 Is Associated with Decreases in Neuronal Activity

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Shmuel,  A
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Augath,  MA
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Oeltermann,  A
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Pauls,  J
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Murayama,  Y
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Shmuel, A., Augath, M., Oeltermann, A., Pauls, J., Murayama, Y., & Logothetis, N. (2003). The Negative BOLD Response in Monkey V1 Is Associated with Decreases in Neuronal Activity. Poster presented at 9th International Conference on Functional Mapping of the Human Brain (HBM 2003), New York, NY, USA.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-DC67-B
Abstract
Negative BOLD responses (NBRs; i.e. below baseline) are pervasive in human fMRI experiments, but commonly ignored. A recent study characterized a robust sustained NBR in the human occipital cortex, triggered by stimulating part of the visual-field (Shmuel et al., 2002). The NBR depends on the pattern of neuronal activity and is coupled to the positive BOLD response (PBR). The NBR is correlated with reductions in cerebral blood flow (CBF) and with decreases in oxygen consumption. The findings from this human study corroborate contributions to the NBR by 1) a significant component of reduction in neuronal activity and possibly 2) a component of hemodynamic changes independent of the local changes in neuronal activity.