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Water and Metabolite Diffusion in Tissue


Pfeuffer,  J
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Pfeuffer, J. (2002). Water and Metabolite Diffusion in Tissue. Talk presented at 24th Discussion Meeting "Magnetic Resonance and Molecular Interactions" of the German Chemical Society. Bremen, Germany. 2002-09-24 - 2002-09-27.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-DF26-9
In Vivo MR Spectroscopy at large diffusion weighting can specifically look at intracellular components of tissue that are characterized by restricted diffusion and a small apparent diffusion coefficient. Beyond water, 1H MRS of metabolites at large diffusion weighting proved to be very useful to separate extra- and intracellular contributions of metabolites in the brain. Further application of diffusion-weighted MRS with other nuclei than 1H, e.g., 31P, 19F, 7Li, 13C, can be utilized to answer specific questions tied to various animal models of disease like ischemia, excitotoxicity, tumor or hydrocephalus (1). Such diffusion-weighted spectroscopy is a powerful tool, using information tied to different compartments, different metabolites, and different tracers.