English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Frontocortical N-acetylaspartate reduction associated with long-term IV heroin use

MPS-Authors
There are no MPG-Authors available
External Ressource
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Haselhorst, R., Dürsteler-MacFarland, K., Scheffler, K., Ladewig, D., Müller-Spahn, F., Stohler, R., et al. (2002). Frontocortical N-acetylaspartate reduction associated with long-term IV heroin use. Neurology, 58(2), 305-307. doi:10.1212/WNL.58.2.305.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-E064-5
Abstract
To examine possible metabolic frontal lobe alterations in IV heroin-dependent patients with different histories of concomitant substance use, N-acetylaspartate (NAA), a putative marker of neuronal viability, was measured by 1H-MRS. Compared with controls, NAA levels in patients were reduced by 7 in gray matter (p = 0.015) but not in white matter. To what extent comorbid conditions or substance use, including alcohol, contributed to these frontocortical metabolic changes remains to be elucidated.