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Frontocortical N-acetylaspartate reduction associated with long-term IV heroin use

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Dürsteler-MacFarland KM, Scheffler,  K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zitation

Haselhorst, R., Dürsteler-MacFarland KM, Scheffler, K., Ladewig D, Müller-Spahn F, Stohler R, Seelig, J., & Seifritz, E. (2002). Frontocortical N-acetylaspartate reduction associated with long-term IV heroin use. Neurology, 58(2), 305-307. doi:10.1212/WNL.58.2.305.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0013-E064-5
Zusammenfassung
To examine possible metabolic frontal lobe alterations in IV heroin-dependent patients with different histories of concomitant substance use, N-acetylaspartate (NAA), a putative marker of neuronal viability, was measured by 1H-MRS. Compared with controls, NAA levels in patients were reduced by 7 in gray matter (p = 0.015) but not in white matter. To what extent comorbid conditions or substance use, including alcohol, contributed to these frontocortical metabolic changes remains to be elucidated.