Aluminum-27 nuclear magnetic resonance spectroscopy and imaging of the human 
gastric lumen

Kaspar, A; Bilecen, D; Scheffler, K; Seelig, J

doi:10.1002/mrm.1910360202

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Aluminum-27 nuclear magnetic resonance spectroscopy and imaging of the human gastric lumen

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https://onlinelibrary.wiley.com/doi/epdf/10.1002/mrm.1910360202
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Kaspar, A., Bilecen, D., Scheffler, K., & Seelig, J. (1996). Aluminum-27 nuclear magnetic resonance spectroscopy and imaging of the human gastric lumen. Magnetic Resonance in Medicine, 36(2), 177-182. doi:10.1002/mrm.1910360202.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-EB40-E

Abstract

Aluminum NMR is proposed as a new imaging and spectroscopy modality. Its potential is exemplified by in vivo studies of the human stomach. The dissolution kinetics of aluminum-containing drugs at physiological doses and their removal from the human stomach have been followed by 27Al magnetic resonance spectroscopy (MRS). Aluminum concentrations as low as 0.5 mg Al3+ in the human stomach can be detected. The time course of gastric emptying has been visualized with 27Al magnetic resonance imaging (MRI) under normal conditions and in the presence of an antimuscarinic agent, which reduces the gastric motor function. 27Al MRI is the only direct method to visualize the gastric pH. 27Al MRI opens new possibilities for medical and pharmaceutical science.