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Journal Article

Elongation factor P: Function and effects on bacterial fitness.

MPS-Authors
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Dörfel,  L. K.
Department of Physical Biochemistry, MPI for biophysical chemistry, Max Planck Society;

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Rodnina,  M. V.
Department of Physical Biochemistry, MPI for biophysical chemistry, Max Planck Society;

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Citation

Dörfel, L. K., & Rodnina, M. V. (2013). Elongation factor P: Function and effects on bacterial fitness. Biopolymers, 99(11), 837-845. doi:10.1002/bip.22341.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-F8DD-5
Abstract
The elongation phase of translation is promoted by three universal elongation factors, EF-Tu, EF-Ts, and EF-G in bacteria and their homologs in archaea and eukaryotes. Recent findings demonstrate that the translation of a subset of mRNAs requires a fourth elongation factor, EF-P in bacteria or the homologous factors a/eIF5A in other kingdoms of life. EF-P prevents the ribosome from stalling during the synthesis of proteins containing consecutive Pro residues, such as PPG, PPP, or longer Pro clusters. The efficient and coordinated synthesis of such proteins is required for bacterial growth, motility, virulence, and stress response. EF-P carries a unique post-translational modification which contributes to its catalytic proficiency. The modification enzymes, which are lacking in higher eukaryotes, provide attractive new targets for the development of new, highly specific antimicrobials.