Solution- and solid-phase synthesis of the polybasic lipid-modified C termini 
of Rho A and K-Ras 4B

Ludolph, Björn; Eisele, Frank; Waldmann, Herbert

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Solution- and solid-phase synthesis of the polybasic lipid-modified C termini of Rho A and K-Ras 4B

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Ludolph, Björn
Max Planck Institute of Molecular Physiology, Max Planck Society;

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Waldmann, Herbert
Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Citation

Ludolph, B., Eisele, F., & Waldmann, H. (2002). Solution- and solid-phase synthesis of the polybasic lipid-modified C termini of Rho A and K-Ras 4B. ChemBioChem, 3(9): 1, pp. 901-904. Retrieved from http://dx.doi.org/10.1002/1439-7633(20020902)3:9<901:AID-CBIC901>3.0.CO;2-U.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-0E11-4

Abstract

Phasing the problem: Polybasic, farnesylated, and fluorescence- or biotin-tagged K-Ras 4B (1) and Rho A peptides can be efficiently synthesized in solution or on a solid support by employment of a combination of Fmoc and Aloc urethanes with trityl groups and a trityl linker. The synthesis methods described in both solid and solution phases present new opportunities for future investigation of areas such as membrane targeting by Ras, Rho, and related lipidated proteins. Biot = biotin, Aca = aminocaproic acid.