Chemo-enzymatic synthesis of the C₁₅-C₂₃ unit of leptomycin B

Scheck, Michael; Waldmann, Herbert

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Chemo-enzymatic synthesis of the C₁₅-C₂₃ unit of leptomycin B

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Scheck, Michael
Max Planck Institute of Molecular Physiology, Max Planck Society;

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Waldmann, Herbert
Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Citation

Scheck, M., & Waldmann, H. (2002). Chemo-enzymatic synthesis of the C₁₅-C₂₃ unit of leptomycin B. Canadian Journal of Chemistry - Revue Canadienne de Chimie, 80(6): 1, pp. 571-576. Retrieved from http://article.pubs.nrc-cnrc.gc.ca/ppv/RPViewDoc?_handler_=HandleInitialGet&journal=cjc&volume=80&calyLang=eng&articleFile=v02-070.pdf.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-0E78-F

Abstract

The asymmetric synthesis of the C-15-C-23 unit of Leptomycin B (LMB) is described. All four stereocenters of the C-15-C-23 unit were prepared from one building block exhibiting only one stereocenter. This building block was synthesized via either an enzymatic transformation or starting from a chiral reagent.