English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

New indene-derivatives with anti-proliferative properties

MPS-Authors

Karaguni,  Ioanna-Maria
Max Planck Institute of Molecular Physiology, Max Planck Society;

Langerak,  Anette
Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons98712

Müller,  Oliver
Sonstige Wissenschaftliche Organisationseinheiten, Max Planck Institute of Molecular Physiology, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Karaguni, I.-M., Glusenkamp, K.-H., Langerak, A., Geisen, C., Ullrich, V., Winde, G., et al. (2002). New indene-derivatives with anti-proliferative properties. Bioorganic & Medicinal Chemistry Letters, 12(4): 1, pp. 709-713. Retrieved from http://dx.doi.org/10.1016/S0960-894X(01)00839-3.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-0EE1-0
Abstract
Metabolites of the non-steroidal anti-inflammatory drug Sulindac inhibit cell proliferation by affecting several intracellular signaling pathways including the tumorigenic Ras/Raf/MAPK pathway. Here, we report the synthesis of eight new indene derivatives derived from the Sulindac structure, and present data on their anti-proliferative properties and their effects on the p21ras protein. (C) 2002 Elsevier Science Ltd. All rights reserved.