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Journal Article

Alchemy, enzymes, and the blind-watchmaker

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Barbas III, C. F., & List, B. (1998). Alchemy, enzymes, and the blind-watchmaker. Nature Biotechnology, 16(5), 423-424. doi:10.1038/nbt0598-423.

Cite as: http://hdl.handle.net/11858/00-001M-0000-0014-A4F7-E
Since the beginning of the modern era of chemistry, a recurring dream of chemists has been to possess a knowledge and understanding sufficient to allow them to create new enzymes at will. The road toward acquiring this knowledge is arduous, but promises to be a rewarding path for many years to come. To date, activities in this field have been divided into research to create truly new catalysts and research directe d at coaxing Nature's wonderful enzymes into accepting slightly different substrates or working under modified conditions. The article by Ikuo Fujii et al. in this issue reports one of the first successful couplings of these strategies.