Enantioselective Aldol Cyclodehydrations Catalyzed by Antibody 38C2

List, Benjamin; Lerner, Richard A.; Barbas III, Carlos F.

doi:10.1021/ol9905405

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Enantioselective Aldol Cyclodehydrations Catalyzed by Antibody 38C2

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List, B., Lerner, R. A., & Barbas III, C. F. (1999). Enantioselective Aldol Cyclodehydrations Catalyzed by Antibody 38C2. Organic Letters, 1(1), 59-62. doi:10.1021/ol9905405.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-A4F0-B

Abstract

Aldolase antibody 38C2 catalyzes the enantioselective aldol cyclodehydration of 4-substituted-2,6-heptanediones (3) to give enantiomerically enriched 5-substituted-3-methyl-2-cyclohexen-1-ones (4). Yields, enantioselectivities, and product purities are markedly increased compared to the l-proline-catalyzed reactions.