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Journal Article

Enantioselective aldol cyclodehydrations catalyzed by antibody 38C2

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List,  Benjamin
Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Skaggs Institute for Chemical Biology and the Department of Molecular Biology, The Scripps Research Institute;

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Citation

List, B., Lerner, R. A., & Barbas, C. F. (1999). Enantioselective aldol cyclodehydrations catalyzed by antibody 38C2. Organic Letters, 1(1), 59-62. doi:10.1021/ol9905405.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0014-A4F0-B
Abstract
Aldolase antibody 38C2 catalyzes the enantioselective aldol cyclodehydration of 4-substituted-2,6-heptanediones (3) to give enantiomerically enriched 5-substituted-3-methyl-2-cyclohexen-1-ones (4). Yields, enantioselectivities, and product purities are markedly increased compared to the l-proline-catalyzed reactions.