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An Efficient Benchtop System for Multigram-Scale Kinetic Resolutions Using Aldolase Antibodies

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Citation

Turner, J. M., Bui, T., Lerner, R. A., Barbas III, C. F., & List, B. (2000). An Efficient Benchtop System for Multigram-Scale Kinetic Resolutions Using Aldolase Antibodies. Chemistry – A European Journal, 6(15), 2772-2774. doi:10.1002/1521-3765(20000804)6:15<2772:AID-CHEM2772>3.0.CO;2-J.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0014-A4E1-D
Abstract
The preparative scale kinetic resolution of racemic aldols 1‐4 using aldolase antibodies 38C2 (Aldrich no. 47 995–0) and 84G3 (Aldrich no. 52 785–8) is described. These reactions use a biphasic aqueous/organic solvent system that allows the catalyst to be reused. Reaction scales range from miligrams to grams, with 0.0086 to 0.12 mol % of antibody binding sites. Because antibodies 38C2 and 84G3 have opposite enantioselectivities, both aldol product enantiomers are accessible by kinetic resolution.