New mechanistic studies on the proline-catalyzed aldol reaction

List, Benjamin; Hoang, Linh; Martin, Harry J.

doi:10.1073/pnas.0307979101

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New mechanistic studies on the proline-catalyzed aldol reaction

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List, Benjamin
Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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List, B., Hoang, L., & Martin, H. J. (2004). New mechanistic studies on the proline-catalyzed aldol reaction. Proceedings of the National Academy of Sciences of the United States of America, 101(16), 5839-5842. doi:10.1073/pnas.0307979101.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-A4B8-9

Abstract

The mechanism of the proline-catalyzed aldol reaction has stimulated considerable debate, and despite limited experimental data, at least five different mechanisms have been proposed. Complementary to recent theoretical studies we have initiated an experimental program with the goal of clarifying some of the basic mechanistic questions concerning the proline-catalyzed aldol reaction. Here we summarize our discoveries in this area and provide further evidence for the involvement of enamine intermediates.