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Catalytic One-Pot, Three-Component Acyl-Strecker Reaction

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Pan,  Subhas Chandra
Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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List,  Benjamin
Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Pan, S. C., & List, B. (2007). Catalytic One-Pot, Three-Component Acyl-Strecker Reaction. Synlett, (2), 318-320. doi:10.1055/s-2007-968008.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0014-A456-7
Abstract
Different aldehydes and amines react with acyl cyanides in the presence of a catalytic amount of the Schreiner thiourea catalyst to give the corresponding N-acyl amino nitriles in high yields. The scope of the reaction is broad and both aromatic and aliphatic aldehydes and amines can readily be used.