English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Total Synthesis of Amphidinolide F

MPS-Authors
/persons/resource/persons132854

Valot,  Gaëlle
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

/persons/resource/persons58920

Regens,  Christopher S.
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

/persons/resource/persons132856

O'Malley,  Daniel P.
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

/persons/resource/persons132858

Godineau,  Edouard
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

/persons/resource/persons132860

Takikawa,  Hiroshi
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

/persons/resource/persons58380

Fürstner,  Alois
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)

anie_201301700_sm_miscellaneous_information.pdf
(Supplementary material), 7MB

Citation

Valot, G., Regens, C. S., O'Malley, D. P., Godineau, E., Takikawa, H., & Fürstner, A. (2013). Total Synthesis of Amphidinolide F. Angewandte Chemie International Edition, 52(36), 9534-9538. doi:10.1002/anie.201301700.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-A3B5-8
Abstract
Orchestrated yet nonconsonant: The challenge posed by the “umpoled” 1,4-dioxygenation pattern characteristic for the polyketide frame of amphidinolide F was mastered by a late-stage ring-closing alkyne metathesis followed by a directed transannular hydration under the aegis of a carbophilic π-acid catalyst. This concordant strategy enabled a concise total synthesis of this enticing marine natural product.