Synthesis of the (9S, 18R)-seco acid of the leukocyte adhesion inhibitor 
cyclamenol A

Nazare, M; Waldmann, Herbert

doi:10.1016/S0040-4039(99)02135-8

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Synthesis of the (9S, 18R)-seco acid of the leukocyte adhesion inhibitor cyclamenol A

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Waldmann, Herbert
Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Nazare, M., & Waldmann, H. (2000). Synthesis of the (9S, 18R)-seco acid of the leukocyte adhesion inhibitor cyclamenol A. TETRAHEDRON LETTERS, 41(5), 625-628. doi:10.1016/S0040-4039(99)02135-8.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-6F17-8

Abstract

Cyclamenol A is a naturally occurring inhibitor of leukocyte adhesion to endothelial cells. The (9S,18R) diastereomer of cyclamenol A seco acid was synthesized by employing Sonogashira couplings and olefination reactions as the key steps. (C) 2000 Elsevier Science Ltd. Air rights reserved.