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Synthesis of characteristic palmitoylated lipopeptides from human Y-1 receptor by a combination of enzyme-labile and Pd(0)-sensitive protecting groups

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Waldmann,  Herbert
Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Citation

Kuhn, K., & Waldmann, H. (1999). Synthesis of characteristic palmitoylated lipopeptides from human Y-1 receptor by a combination of enzyme-labile and Pd(0)-sensitive protecting groups. TETRAHEDRON LETTERS, 40(35), 6369-6372. doi:10.1016/S0040-4039(99)01388-X.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-7114-0
Abstract
Base-labile palmitoylated peptides representing the characteristic lipidated region of human Y-1 receptor were synthesizea via a chemoenzymatic protecting group strategy employing both the enzyme catalyzed cleavage of the choline ester and the Pd(0)mediated removal of the allyl ester as the key steps. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.