English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Synthesis and in vitro evaluation of the farnesyltransferase inhibitor pepticinnamin E

MPS-Authors
/persons/resource/persons98735

Waldmann,  Herbert
Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

External Ressource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Hinterding, K., Hagenbuch, P., Retey, J., & Waldmann, H. (1999). Synthesis and in vitro evaluation of the farnesyltransferase inhibitor pepticinnamin E. CHEMISTRY-A EUROPEAN JOURNAL, 5(1), 227-236. doi:10.1002/(SICI)1521-3765(19990104)5:1<227:AID-CHEM227>3.0.CO;2-X.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0014-7130-0
Abstract
The farnesyltransferase inhibitor pepticinnamin E was synthesized and shown to have the S configuration at the central, non-proteinogenic amino acid. Using a recombinant yeast farnesyltransferase the biological activity of the natural product and structural analogues was determined. It was shown that pepticinnamin E is a bisubstrate inhibitor. Furthermore, several structural parameters were identified that decisively influence inhibition of the farnesyl transfer.