Continuous biocatalytic synthesis of (R)-2-octanol with integrated product 
separation

Kohlmann, Christina; Leuchs, Susanne; Greiner, Lasse; Leitner, Walter

doi:10.1039/c0gc00790k

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Continuous biocatalytic synthesis of (R)-2-octanol with integrated product separation

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Leitner, Walter
Institut für Technische und Makromolekulare Chemie, RWTH Aachen University;
Service Department Leitner (Technical Labs), Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Kohlmann, C., Leuchs, S., Greiner, L., & Leitner, W. (2011). Continuous biocatalytic synthesis of (R)-2-octanol with integrated product separation. Green Chemistry, 13(6), 1430-1436. doi:10.1039/c0gc00790k.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-A307-1

Abstract

The continuous biocatalytic synthesis of (R)-2-octanol carried out in an enzyme membrane reactor showed an excellent process stability of the biocatalysts, resulting in a turnover number of 15 million for the applied alcohol dehydrogenase. Utilisation of the ionic liquid AMMOENG^TM 101 as a feasible cosolvent increased substrate concentration, and improved space time yields and turnover numbers of the cofactor by factors of 3 and 6, respectively. Moreover, 80% less waste was generated, while producing the same amount of product. Integrated product separation was realized via solid phase extraction. Extraction of the applied solid phase with supercritical carbon dioxide allowed more than 30 reuses of the solid phase.