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Journal Article

Genome-wide mapping of gene–microbiota interactions in susceptibility to autoimmune skin blistering

MPS-Authors
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Srinivas,  Girish
Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Wang,  Jun
Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Künzel,  Sven
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Baines,  John F.
Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

External Resource
Fulltext (public)

Srinivas_2013.pdf
(Publisher version), 899KB

Supplementary Material (public)

Supplementary_Data_6.zip
(Supplementary material), 34MB

Citation

Srinivas, G., Möller, S., Wang, J., Künzel, S., Zillikens, D., Baines, J. F., et al. (2013). Genome-wide mapping of gene–microbiota interactions in susceptibility to autoimmune skin blistering. Nature Communications, 4: 2462. doi:10.1038/ncomms3462.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0014-AADE-1
Abstract
Susceptibility to chronic inflammatory diseases is determined by immunogenetic and environmental risk factors. Resident microbial communities often differ between healthy and diseased states, but whether these differences are of primary aetiological importance or secondary to the altered inflammatory environment remains largely unknown. Here we provide evidence for host gene–microbiota interactions contributing to disease risk in a mouse model of epidermolysis bullosa acquisita, an autoantibody-induced inflammatory skin disease. Using an advanced intercross, we identify genetic loci contributing to skin microbiota variability, susceptibility to skin blistering and their overlap. Furthermore, by treating bacterial species abundances as covariates with disease we reveal a novel disease locus. The majority of the identified covariate taxa are characterized by reduced abundance being associated with increased disease risk, providing evidence of a primary role in protection from disease. Further characterization of these putative probiotic species or species assemblages offers promising potential for preventative and therapeutic treatment development.