Reversible stabilization of transition-metal-binding DNA G-quadruplexes.

Engelhard, D. M.; Pievo, R.; Clever, G. H.

doi:10.1002/anie.201307594

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Reversible stabilization of transition-metal-binding DNA G-quadruplexes.

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Pievo, R.
Research Group of Electron Paramagnetic Resonance, MPI for Biophysical Chemistry, Max Planck Society;

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Citation

Engelhard, D. M., Pievo, R., & Clever, G. H. (2013). Reversible stabilization of transition-metal-binding DNA G-quadruplexes. Angewandte Chemie-International Edition, 52(49), 12843-12847. doi:10.1002/anie.201307594.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-C680-4

Abstract

You can't top the CopperTop: Tetramolecular G-quadruplexes modified with terminal pyridine ligands exhibit metal-triggered stabilization as monitored by thermal denaturation studies, circular dichroism, and nondenaturing gel electrophoresis. Formation of the square-planar CuII(pyridine)4 complex was confirmed by EPR measurements. The metal complexation is fully reversible by removal of the transition metal with ethylenediaminetetraacetic acid (edta).