English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Hypnotizability and Catechol-O-Methyltransferase (COMT) polymorphysms in Italians

MPS-Authors
/persons/resource/persons32812

Gialluisi,  Alessandro
Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society;
International Max Planck Research School for Language Sciences, MPI for Psycholinguistics, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

Presciuttini_etal_2014.pdf
(Publisher version), 299KB

Supplementary Material (public)
There is no public supplementary material available
Citation

Presciuttini, S., Gialluisi, A., Barbuti, S., Curcio, M., Scatena, F., Carli, G., et al. (2014). Hypnotizability and Catechol-O-Methyltransferase (COMT) polymorphysms in Italians. Frontiers in Human Neuroscience, 7: 929. doi:10.3389/fnhum.2013.00929.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-F50C-C
Abstract
Higher brain dopamine content depending on lower activity of Catechol-O-Methyltransferase (COMT) in subjects with high hypnotizability scores (highs) has been considered responsible for their attentional characteristics. However, the results of the previous genetic studies on association between hypnotizability and the COMT single nucleotide polymorphism (SNP) rs4680 (Val158Met) were inconsistent. Here, we used a selective genotyping approach to re-evaluate the association between hypnotizability and COMT in the context of a two-SNP haplotype analysis, considering not only the Val158Met polymorphism, but also the closely located rs4818 SNP. An Italian sample of 53 highs, 49 low hypnotizable subjects (lows), and 57 controls, were genotyped for a segment of 805 bp of the COMT gene, including Val158Met and the closely located rs4818 SNP. Our selective genotyping approach had 97.1% power to detect the previously reported strongest association at the significance level of 5%. We found no evidence of association at the SNP, haplotype, and diplotype levels. Thus, our results challenge the dopamine-based theory of hypnosis and indirectly support recent neuropsychological and neurophysiological findings reporting the lack of any association between hypnotizability and focused attention abilities.