Mineralized self-assembled peptides on 3D laser-made scaffolds: a new route 
toward 'scaffold on scaffold' hard tissue engineering

Terzaki, K.; Kalloudi, E.; Mossou, E.; Mitchell, E. P.; Forsyth, V. T.; Rosseeva, E.; Simon, P.; Vamvakaki, M.; Chatzinikolaidou, M.; Mitraki, A.; Farsari, M.

doi:10.1088/1758-5082/5/4/045002

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Mineralized self-assembled peptides on 3D laser-made scaffolds: a new route toward 'scaffold on scaffold' hard tissue engineering

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Rosseeva, E.
Max Planck Institute for Chemical Physics of Solids, Max Planck Society;

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Simon, P.
Paul Simon, Chemical Metal Science, Max Planck Institute for Chemical Physics of Solids, Max Planck Society;

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引用

Terzaki, K., Kalloudi, E., Mossou, E., Mitchell, E. P., Forsyth, V. T., Rosseeva, E., Simon, P., Vamvakaki, M., Chatzinikolaidou, M., Mitraki, A., & Farsari, M. (2013). Mineralized self-assembled peptides on 3D laser-made scaffolds: a new route toward 'scaffold on scaffold' hard tissue engineering. Biofabrication, 5(4):, pp. 045002-1-045002-14. doi:10.1088/1758-5082/5/4/045002.

引用: https://hdl.handle.net/11858/00-001M-0000-0015-1E10-9

要旨

In this study, we propose a new approach to hard tissue regeneration based on the mineralization of 3D scaffolds made using lasers. To this end, we report the rational design of aspartate-containing self-assembling peptides targeted for calcium binding. We further investigate the suitability of these peptides to support cell attachment and proliferation when coupled on a hybrid organic-inorganic structurable material, and evaluate the response of pre-osteoblastic cells on functionalized 3D scaffolds and material surfaces. Our results show that the mineralized peptide, when immobilized on a hybrid photo-structurable material strongly supports cell adhesion, a proliferation increase after three and seven days in culture, and exhibits a statistically significant increase of biomineralization. We propose this strategy as a 'scaffold on scaffold' approach for hard tissue regeneration.